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A Schematic illustration of ROS-mediated anticancer activity of GQDs in TNBC. (a) Green electrochemical synthesis of GQDs using <t>graphene</t> <t>sheets,</t> NaOH, and vitamin C. (b) Passive tumor accumulation via the EPR effect after intravenous injection. (c) Receptor-mediated uptake in TNBC cells. (d) Intracellular ROS generation induces mitochondrial damage, Bid activation, and GSH depletion.
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A Schematic illustration of ROS-mediated anticancer activity of GQDs in TNBC. (a) Green electrochemical synthesis of GQDs using graphene sheets, NaOH, and vitamin C. (b) Passive tumor accumulation via the EPR effect after intravenous injection. (c) Receptor-mediated uptake in TNBC cells. (d) Intracellular ROS generation induces mitochondrial damage, Bid activation, and GSH depletion.

Journal: ACS Omega

Article Title: Electrochemically Engineered GQDs for Selective Tumor Targeting and Oxidative Nanotherapy in Triple-Negative Breast Cancer

doi: 10.1021/acsomega.5c10310

Figure Lengend Snippet: A Schematic illustration of ROS-mediated anticancer activity of GQDs in TNBC. (a) Green electrochemical synthesis of GQDs using graphene sheets, NaOH, and vitamin C. (b) Passive tumor accumulation via the EPR effect after intravenous injection. (c) Receptor-mediated uptake in TNBC cells. (d) Intracellular ROS generation induces mitochondrial damage, Bid activation, and GSH depletion.

Article Snippet: Graphene sheets (purity >99%, CAS No. 1034343–98–0) were purchased from Graphenea Inc. (San Sebastián, Spain).

Techniques: Activity Assay, Injection, Activation Assay